Photo by Mike from Mandeville

Hotels in Destrehan

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
Apr 23 - Apr 24
Tomorrow
Apr 24 - Apr 25
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

Where to stay in Destrehan?

Comfort Inn New Orleans Airport South
Laptop workspace, blackout drapes, iron/ironing board

Comfort Inn New Orleans Airport South

2.5 star property
7.8 out of 10, Good, (1001)
The price is $96
includes taxes & fees
$84 per night
Apr 29 - Apr 30
Comfort Inn New Orleans Airport South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Destrehan

A lot of history with these plantations. This was a nice one.

Destrehan Plantation

Destrehan Plantation is just one of the landmarks located 0.8 mi (1.4 km) from central Destrehan, so you might want to stop by for a few pics during your trip.

See properties in Destrehan Plantation
Destrehan Plantation

Ochsner Health Center For Children - Destrehan

Ochsner Health Center For Children - Destrehan is a hospital located 1 mi (1.6 km) from central Destrehan.

See properties in Ochsner Health Center For Children - Destrehan
Ochsner Health Center For Children - Destrehan

Learn more about Destrehan

The region around Destrehan is home to attractions such as Mississippi River and Pontchartrain Center.

See all hotels in Destrehan
A lot of history with these plantations. This was a nice one.
Photo by Mike from Mandeville
Open Photo by Mike from Mandeville
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

What accommodations do travelers recommend in Destrehan?
Guests like Clarion Hotel New Orleans - Airport & Conference Center.
Can I book refundable hotels in Destrehan?
If you want the flexibility to change your plans to Destrehan, most properties offer refundable* rates you can book. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Destrehan be like during my visit?
The warmest months in Destrehan are usually August and July with an average temp of 82°F. January and February are the chilliest months when the average temp is 58°F. The rainiest months are August and July.
Why should I book my Destrehan hotel through Hotels.com?
There are plenty of reasons to book your Destrehan travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals