Hotels in Saint James City

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Check prices for these dates

Tonight
Apr 25 - Apr 26
Tomorrow
Apr 26 - Apr 27
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

Where to stay in Saint James City?

Marriott Sanibel Harbour Resort & Spa
On the beach, white sand, kayaking, motor boating

Marriott Sanibel Harbour Resort & Spa

4.0 star property
8.4 out of 10, Very Good, (1004)
The price is $261
includes taxes & fees
$234 per night
May 11 - May 12
Marriott Sanibel Harbour Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Saint James City

The region around Saint James City is home to attractions such as J. N. Ding Darling National Wildlife Refuge and Periwinkle Way.

See all hotels in Saint James City
Saint James City showing a bay or harbor
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers like in Saint James City?
Guests like Margaritaville Beach Resort Fort Myers, Lani Kai Beachfront Resort and Marriott Sanibel Harbour Resort & Spa.
Can I book a refundable hotel in Saint James City?
If you want the flexibility to change your plans to Saint James City, most properties offer refundable* rates you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Saint James City?
Your animal companion is welcome at this pet-friendly hotel: Off the Charts Inn & Out Island Resort.
Where can I stay in Saint James City if I want a vacation rental instead of a traditional hotel?
If you want a good alternative to a hotel, browse our selection of 122 vacation homes. In addition, there are 6 apartments and 10 condos.
Where can I stay if I'm traveling to Saint James City for a family-friendly trip?
Your kids are welcome at 2022/2023 in Florida! Peace & tranquility awaits!.
Where should I stay in Saint James City for a vacation with my partner?
2022/2023 in Florida! Peace & tranquility awaits! is a great option for a romantic getaway.
What will the weather in Saint James City be like during my trip?
August and July are typically the warmest months in Saint James City when the average temp is 83°F. January and February are the coldest months when the average temperature is 68°F. August and June are the months with the most rain.
Why should I book my Saint James City accommodation with Hotels.com?
There are lots of reasons to book your Saint James City trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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