Hotels in Mesopotamia

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
May 2 - May 3
Tomorrow
May 3 - May 4
This weekend
May 2 - May 4
Next weekend
May 9 - May 11

Where to stay in Mesopotamia?

O2 Hotel Gualeguaychú
Front of property

O2 Hotel Gualeguaychú

2.5 star property
7.6 out of 10, Good, (56)
The price is $40
$40 per night
May 4 - May 5
O2 Hotel Gualeguaychú
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Mesopotamia

Carpinchos

El Palmar National Park

Immerse yourself in nature and spend the day at El Palmar National Park, located 8.2 mi (13.2 km) from central Ubajay.

See properties in El Palmar National Park
El Palmar National Park

Learn more about Mesopotamia

Notable for its natural beauty, Mesopotamia features attractions such as Termas de Chajarí and Termas Federacion Water Park. This romantic city has something for everyone including sights like Termas de Federacion and Santa Rita de Casia Church.

See all hotels in Mesopotamia
Mesopotamia showing a river or creek and forest scenes
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

What hotels do travelers like in Mesopotamia?
Casa Chic Carmelo, Club Valle Termal Resort and Costarenas Hotel & Spa are all accommodations that are popular with guests.
Can I book a refundable accommodation in Mesopotamia?
If you’re looking for the flexibility to change your plans to Mesopotamia, most properties offer refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Where should I consider staying in Mesopotamia if I want a budget-friendly accommodation?
An inexpensive option worth considering is O2 Gualeguaychú.
Where can I stay in Mesopotamia if I want a vacation rental instead of a traditional hotel?
Browse 13 vacation homes on our site. You also might want to consider one of 18 apartments or 10 cabins.
Why should I book my Mesopotamia hotel through Hotels.com?
There are lots of reasons to book your Mesopotamia trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals